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Journal Article 8

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nonalcoholic fatty liver disease 4

Gut microbiota 2

hepatocellular carcinoma 2

obesity 2

Akkermansia muciniphila 1

Dysbiosis 1

Gut barrier function 1

Hepatocellular carcinoma 1

NAFLD 1

NASH 1

Non-alcoholic steatohepatitis 1

Nonalcoholic fatty liver disease 1

Pien Tze Huang 1

Tumorigenesis 1

alcoholic liver disease 1

autoimmune liver diseases 1

continuous glucose monitoring 1

hepatitis B virus and hepatitis C virus infection 1

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miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 389-396 doi: 10.1007/s11684-016-0468-5

Abstract:

Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver cirrhosis and hepatocellular carcinoma and is a considerable threat to public health. miRNAs are important post-transcriptional regulators of gene expression, and the dysregulation of miRNAs is involved in various biological processes in the liver, including lipid homeostasis, inflammation, apoptosis, and cell proliferation. Recently, a number of studies have described the association between miRNAs and NAFLD progression and have shown that circulating miRNAs reflect histological changes in the liver. Therefore, circulating miRNAs have potential use for the evaluation of NAFLD severity. In this review, we discuss the involvement of miRNAs in NAFLD pathogenesis and the key role of miRNAs in the screening, diagnosis, and staging of NAFLD.

Keywords： nonalcoholic fatty liver disease     nonalcoholic steatohepatitis     hepatocellular carcinoma     miRNA    

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Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 667-685 doi: 10.1007/s11684-022-0960-z

Abstract: Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of metabolic syndrome and a commonthe therapeutic potential of A. muciniphila for NAFLD, especially in the inflammatory stage, nonalcoholicsteatohepatitis.

Keywords： Akkermansia muciniphila     NAFLD     NASH     steatosis     inflammation    

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Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Engineering doi: 10.1016/j.eng.2022.10.010

Abstract: Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease without effectiveWe found that PTH prevented the development of steatohepatitis induced by various dietary models, includingThe enriched L. acidophilus prevented MCD diet-induced steatohepatitis.In addition, PTH restored the gut barrier function in mice with steatohepatitis, as evidenced by reducedIn conclusion, PTH protects against steatohepatitis development by modulating the gut microbiota and

Keywords： Pien Tze Huang     Non-alcoholic steatohepatitis     Gut barrier function     Gut microbiota    

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Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai

Frontiers of Medicine 2007, Volume 1, Issue 4,   Pages 413-417 doi: 10.1007/s11684-007-0081-8

Abstract: To summarize the pathological features of nonalcoholic liver disease (NAFLD) in China based on a histological
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Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract:

Nonalcoholic fatty liver disease (NAFLD) covers a spectrum of liver disorders ranging from simplesteatosis to advanced pathologies, including nonalcoholic steatohepatitis and cirrhosis.

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

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Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 460-471 doi: 10.1007/s11684-021-0861-6

Abstract: Lifestyle interventions, including dietary adjustments and exercise, are important for obesity management. This study enrolled adults with overweight or obesity to explore whether either low-carbohydrate diet (LCD) or exercise is more effective in metabolism improvement. Forty-five eligible subjects were randomly divided into an LCD group (n=22) and an exercise group (EX, n=23). The subjects either adopted LCD (carbohydrate intake<50 g/day) or performed moderate-to-vigorous exercise (≥30 min/day) for 3 weeks. After the interventions, LCD led to a larger weight loss than EX (−3.56±0.37 kg vs. −1.24±0.39 kg, P<0.001), as well as a larger reduction in fat mass (−2.10±0.18 kg vs. −1.25±0.24 kg, P=0.007) and waist circumference (−5.25±0.52 cm vs. −3.45±0.38 cm, P=0.008). Both interventions reduced visceral and subcutaneous fat and improved liver steatosis and insulin resistance. Triglycerides decreased in both two groups, whereas low-density lipoprotein cholesterol increased in the LCD group but decreased in the EX group. Various glycemic parameters, including serum glycated albumin, mean sensor glucose, coefficient of variability (CV), and largest amplitude of glycemic excursions, substantially declined in the LCD group. Only CV slightly decreased after exercise. This pilot study suggested that the effects of LCD and exercise are similar in alleviating liver steatosis and insulin resistance. Compared with exercise, LCD might be more efficient for weight loss and glucose homeostasis in people with obesity.

Keywords： low-carbohydrate diet     obesity     nonalcoholic fatty liver disease     continuous glucose monitoring     mean    

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NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 249-261 doi: 10.1007/s11684-018-0622-3

Abstract: hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic

Keywords： hepatitis B virus and hepatitis C virus infection     autoimmune liver diseases     alcoholic liver disease     nonalcoholic    

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The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Engineering 2017, Volume 3, Issue 1,   Pages 110-114 doi: 10.1016/J.ENG.2017.01.017

Abstract: determining the occurrence and progression of hepatocarcinoma, chronic liver diseases related to alcohol, nonalcoholic

Keywords： Gut microbiota     Dysbiosis     Tumorigenesis     Hepatocellular carcinoma     Nonalcoholic fatty liver disease    

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Title Author Date Type Operation

miRNAs in non-alcoholic fatty liver disease

Zhen He,Cheng Hu,Weiping Jia

Journal Article

Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge

Journal Article

Pien Tze Huang Protects Against Non-Alcoholic Steatohepatitis by Modulating the Gut Microbiota and Metabolites

Xianyi Zeng,Xiang Zhang,Hao Su,Hongyan Gou,Harry Cheuk-Hay Lau,Xiaoxu Hu,Ziheng Huang,Yan Li,Jun Yu,

Journal Article

Pathological study of 130 cases of nonalcoholic fatty liver disease based on NASH-CRN system

ZHOU Guangde, ZHAO Jingmin, DING Xiaohui, PAN Deng, SUN Yanling, YANG Jianfa, ZHAO Yulai

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Low-carbohydrate diets lead to greater weight loss and better glucose homeostasis than exercise: a randomized clinical trial

Journal Article

NKT cells in liver diseases

Shasha Zhu, Huimin Zhang, Li Bai

Journal Article

The Gut Microbiota, Tumorigenesis, and Liver Diseases

Guishuai Lv, Ningtao Cheng, Hongyang Wang

Journal Article